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Deadlock Bible
Matchup · November 6, 2026

Nurse Harrow vs Vyper

54.3%
Favoured34,331 matches
All Nurse Harrow matchups & counters

Updated · Patch Nov 4, 2026

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How Nurse Harrow beats Vyper

Your game plan as Nurse Harrow

A battlefield medic who heals with her gun, starves enemy buffs with leeches and terrifies anyone who looks her in the eye.

Lane
Throw Leech Therapy on enemies that just used a buff. The leeches eat its duration while they deal damage, and every leech you collect feeds your other abilities.
Mid game
Load Healing Needles when an ally is low: your syringes heal teammates, and dealing damage earns the charges back. Wretched Vapors makes an ally faster and delays the damage they take, so heal them before the crash.
Late game
Lurking Terrors locks down anyone facing you: no stamina, no movement abilities, then fear. Open the bag where the enemy has to look at you, such as a chokepoint or a dive.

How to beat Vyper

A slippery gunner who slides into your backline with a dagger and a bola.

  • 01Stay above half health; Lethal Venom scales with missing health.
  • 02Dodge Petrifying Bola’s direct hit.
  • 03CC her before she slides away.
Per match

Head-to-head

Nurse HarrowVyper
54.3%Win rate45.7%
0.66Kills per death0.91
+0Last-hit edge+21.6
+0Deny edge+0.4
+0Soul lead+2.5K
+0Objective damage edge+7.1K
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Laning

Win the lane: Nurse Harrow into Vyper

  1. 01Vyper wins the farm by ~21.6 last hits per match. Prioritise safe last hits and denies over trades, and let your lane partner zone.
  2. 02Vyper looks for burst windows. Don’t sit in lane at low health, and ping the moment they disappear — they’re hunting.
  3. 03Your own sustain (Healing Needles) wins extended lanes — stay longer than they can.
Skill order

Skill order for this matchup

60% win rate over 90,585 matches

Vyper’s kit

Threats

Lethal Venom
Stun28s cd
Petrifying BolaUltimate
StunSlow115s cd
Screwjab Dagger
Slow10s cd
Nurse Harrow’s kit

Your tools

Wretched Vapors
Slow40s cd
Healing Needles
SlowSustain
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Mid & late game

Winning the fights after lane

  • Nurse Harrow averages 0.66 kills per death against Vyper.
  • Nurse Harrow finishes 2.5k souls behind Vyper on average — play for teamfights and scaling rather than lane kills.
  • Nurse Harrow deals 7.1k less objective damage per match than Vyper — let teammates take structures while you hold.
  • Track Petrifying Bola (115s cooldown). The window right after Vyper uses it is your best time to fight.
Also check

Who else beats Vyper

GravesFavouredGraves vs Vyper62.0%53,158 matchesPaigeFavouredPaige vs Vyper59.8%41,897 matchesSevenFavouredSeven vs Vyper58.4%47,696 matchesRat KingFavouredRat King vs Vyper58.4%71,848 matches
FAQ

Matchup questions

Who wins Nurse Harrow vs Vyper?

Nurse Harrow wins 54.3% of 34,331 recent matches against Vyper — favoured.

How do I beat Vyper as Nurse Harrow?

Vyper wins the farm by ~21.6 last hits per match. Prioritise safe last hits and denies over trades, and let your lane partner zone. Track Petrifying Bola (115s cooldown). The window right after Vyper uses it is your best time to fight.

What should Nurse Harrow buy against Vyper?

Debuff Reducer, Unstoppable, Weapon Shielding.